Homocysteine level in the blood plasma is a risk factor and predictor of Alzheimer’s Disease. Therefore if you scored low in the Cognitive Function Test, it is advisable to follow this up with a homocysteine test. Tests can be obtained via your GP or home testing can be undertaken as below:
In the UK a home-test kit is available from www.yorktest.com
In Eire a home-test kit is available from www.yorktest.ie
In South Africa this is available from a number of laboratories such as Lancet Labs and Ampath.
Supplementation to normalise homocysteine levels
Your homocysteine level is a very good indicator of the amount of certain B vitamins, and other nutrients, you need. Homocysteine can be measured by either your GP or through a home test kit. The chart below shows you the approximate level that is worth supplementing on a daily basis.
|Nutrient||Very low risk||Low risk||At risk||High risk|
|Below 7||7–9||10-15||Above 15|
|NAC or Glutathione*||250mg||500mg||750mg|
|*N-Acetyl Cysteine or glutathione has been shown in studies to help lower homocysteine and improve memory in people with cognitive impairment, given in addition to B12, folic acid and B6.|
If your level is below 7 it is still advisable to take a high potency multivitamin and mineral supplement, especially later in life, providing the levels of nutrients shown in the table above for the purposes of maintaining a healthy low level.
If your level is above 7 you will need to take a supplement containing larger amounts of these nutrients, as well as a high potency multivitamin and mineral. Since most of these are water-soluble you are best to divide the dose and take a supplement two or three times a day. The following supplements provide nutrient levels close to these: (the amounts given are per capsule)
|P Holford||Higher Nature||Solgar Gold Specifics||Betrinac|
|Connect* 3 tables provide:||
H Factors* 2 tablets provide:
|H Modulators 2 tablets provide:||1 tablet provides:|
|Folic Acid||MTHfolate 375mcg*||400mcg||400mcg||800mcg|
|NAC or Glutathione||750mg||-||-||600mcg|
Higher Nature: adopts a formulae that uses methylB12, which is more bioavailable. B12 absorption tends to decline with age and is poor in some people.
Connect: adopts a formulae that uses methylB12 and the methyl form of Folic Acid (B9), which are more bioavailable. The methylated form of folic acid used in this formula is equivalent to 750mcg of unmethylated folic acid.
|These supplements are available in health food stores or by mail order on the web.|
Re-test your homocysteine level after three months. If your homocysteine level has dropped then use the table above to identify the revised supplementation required based on that level. If your level drops below 7 stay on a high potency multivitamin that provides these basic levels. Do not keep taking higher levels of B vitamins, especially folic acid, unless required to keep your homocysteine level in check.