logo
food for the brain

Championing optimum nutrition for the mind


Drug treatment for Schizophrenics may induce diabetes. Saddichha s et al Acta Psychiatr Scand. 2008 May;117(5):342-7. Epub 2008 Feb 26

Paper

 

Drug treatment for Schizophrenics may induce diabetes. Saddichha s et al Acta Psychiatr Scand. 2008 May;117(5):342-7. Epub 2008 Feb 26

Details

There have been innumberable advances in the pharmacotherapy of schizophrenia but problems have emerged hand in glove, such as the presence of treatment-emergent glucose intolerance and frank diabetes mellitus.  This study looked at 99 patients with schizophrenia.  Their 2 h post prandial plasma glucose was tested prior to medication and then again after 6 weeks on medication.  The results were compared with a matched healthy control group.  The study found a significant difference in baseline 2 h post-prandial blood suger between the control group and treatment group as well as significant increase in weight, fasting blood sugar and 2h post-prandial blood sugar from baseline to endpoint between the groups.  It concluded that male patients with schizophrenia were liable to develop Diabetes Mellitus(DM) and antipsychotic treatment may lead to the development of DM in a significant 10% within 6 weeks.

Saddichha s et al 'Diabetes and schizophrenia - effect of disease or drug? Results from a randomized, double-blind, controlled prospective study in first-episode schizophrenia'.Acta Psychiatr Scand. 2008 May;117(5):342-7. Epub 2008 Feb 26

Click here for the abstract