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Elevated homocysteine is a risk factor for dementia and Alzheimer's Disease. Seshadri et al, N Engl J Med., 346(7):476-83, 2002

Paper

 

Elevated homocysteine is a risk factor for dementia and Alzheimer's Disease. Seshadri et al, N Engl J Med., 346(7):476-83, 2002

Details

A total of 1092 subjects without dementia (667 women and 425 men; average age, 76 years) were followed for an average of 8 years. Their homocysteine levels were monitored. Based on their homocysteine levels and those who developed dementia and Alzheimer’s, the authors concluded that an increased level of homocysteine in the blood is a “strong, independent risk factor for the development of dementia and Alzheimer’s Disease”. There was a doubling of risk for Alzheimer’s with a homocysteine level greater than 14mmol/l.

Seshadri S et al,Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.N Engl J Med., 346(7):476-83, 2002

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