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Homocysteine and dementia – a clear association. Wald, Kasturiratne, & Simmonds (2011). Alzheimer's and demntia 7: 412-417

Paper

 

Homocysteine and dementia – a clear association. Wald, Kasturiratne, & Simmonds (2011). Alzheimer's and demntia 7: 412-417

Details

 In a meta-analysis of studies (a collation and analysis of a group of studies on the same topic), the results of eight studies (involving almost 9,000 subjects) found that at 5 µmol/l increase in homocysteine level was associated with a 35% increase in incidence of dementia. (Remember that a healthy level of homocysteine is around 7 µmol/l, although a level of 12 µmol/l is not uncommon amongst the over 50’s population in the UK). While the researchers could not conclude that raised homocysteine is a cause for dementia, they did estimate that if it was, we could expect an approximate 20% reduction in risk of dementia from treatment with folic acid and B12.

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