Lowering homocysteine improved symptoms in chronic schizophrenia patients with elevated homocysteine. Levine J et al, Biol Psychiatry., 60(3):265-9, 2006
Forty-two schizophrenic patients with elevated plasma homocysteine levels were treated with vitamins B6, B12 and folic acid or placebo for 3 months. Homocysteine levels declined with vitamin therapy compared with placebo in all patients. Clinical symptoms of schizophrenia as measured by the Positive and Negative Syndrome Scale declined significantly with the vitamin treatment compared with placebo. The researchers concluded that a subgroup of schizophrenic patients with elevated homocysteine might benefit from the simple addition of B vitamins.
Levine J et al, ‘Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia’, Biol Psychiatry., 60(3):265-9, 2006