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Omega-3 fatty acid EPA improves depression in people with bipolar alongside their existing medication. Frangou, Br J Psychiatry. 188:46-50, 2006

Paper

 

Omega-3 fatty acid EPA improves depression in people with bipolar alongside their existing medication. Frangou, Br J Psychiatry. 188:46-50, 2006

Details

In a 12-week, double-blind study individuals with bipolar depression received either 1 g of EPA a day, 2 g/day or placebo, alongside their existing medication. Effectiveness of this treatment was assessed using the Hamilton Rating Scale for Depression (HRSD), as well as the Young Mania Rating Scale and Clinical Global Impression Scale (CGI). Significant improvement was seen with the EPA compared with placebo in the HRSD (P=0.04) and the CGI (P=0.004) scores. There was no apparent benefit of 2 g over 1 g dose. Both doses were well tolerated.

S Frangou et al., ‘Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study’, Br J Psychiatry, 188:46-50, 2006

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